Useful Links

1. PSI-BLAST Program: namely Position-Specific Iterative BLAST, which is an iterated BLAST program to generate the position-specific scoring matrices (PSSMs) containing the important evolutionary information.

2. PSIPRED Program: This is a high-accurate prediction web server for protein secondary structure assignment which was originally developed by Professor David T Jones and his colleagues in University College London. We used this program to generate the prediction secondary structure information in terms of their probability matrices of three states (i.e., helix, strand and coil) for each residue in a query protein sequence.

3. SVM_light Software: It is an implementation of Vapnik's Support Vector Classification (SVC) and Support Vector Regression (SVR) algorithms which was originally made available by Thorsten Joachims in Cornell University.

4. LIBSVM Software: It is another well-known and widely-used implementation of Vapnik's SVC and SVR algorithms, developed by Chih-Chung Chang and Chih-Jen Lin in National Taiwan University.

5. Protein Explorer Software: This is a free and user-friendly software package aiming to provide the easiest-to-use 3D molecular visualization.

6. UCSF Chimera Package: This is an interactive molecular 3D visualization software. We employed it to render the molecular images in Figure 2 of the revised manuscript.

7. MATHPROG- Maximum-weight Graph Matching Algorithm: This program was written by Ed Rothberg as an implementation of Edmonds-Gabow's weighted matching algorithm, which as a matter of fact has been employed by the majority of previous disulfide-predicting studies to assign each putative disulfide connectivity pattern and thus finalize the prediction.